![]() ![]() The appearance of the reactive ALN may be confused with malignant nodal metastases on oncological imaging. ![]() 4–7 However, paucity of data means that the incidence and expected duration of uptake is not well established, particularly with different vaccine types. ![]() A number of published case reports illustrate increased 18F-FDG uptake in ipsilateral axillary lymph nodes (ALN) after administration of COVID-19 vaccines in the deltoid muscle. This modality uses a glucose analogue to image metabolic activities of various pathologies, predominately tumours, but also inflammation and infection. There is emerging data that describe the effect of COVID-19 vaccine on the 18F-fluorodeoxyglucose positron emission tomography – computed tomography ( 18F-FDG PET-CT) imaging appearances. Local enlarged lymphadenopathy can also occur, however, this is reported as being uncommon at <1 in 100 administrations. Like all vaccines, COVID-19 vaccines carry a potential to cause side effects, of which, the most common being local inflammation at the injection site. 1 The Medicines and Healthcare products Regulatory Agency gave regulatory approval for the Pfizer-BioNTech vaccine in the UK on 02 December 2020, followed by the Oxford-AstraZeneca vaccine on 30 December 2020. The UK had the international lead in rolling out the COVID-19 mass vaccination programme on 08 December 2020. In response to the pandemic, unprecedented investments have been made in vaccine development. While this situation is still ongoing, the resilience of the global society is constantly being challenged. The COVID-19 pandemic has rapidly spread around the world causing devastating effects to millions of people. ![]()
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